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. 2014 Feb 4;22(4):811–820. doi: 10.1038/mt.2013.291

Figure 2.

Figure 2

Lipid composition and physico-chemical characterization of DACC lipoplex. (a) DACC lipoplex consisting of a positively charged lipid system (70 mol% cationic lipid AtuFECT01 (β-L-arginyl-2,3-L-diaminopropionic acid-N-palmityl-N-oleyl-amide trihydrochloride), 1 mol% mPEG2000-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanol amine-N (methoxy (polyethylene glycol)-2000), and 29 mol% cholesterol) and blunt ended siRNA duplexes with alternating 2′-O-methyl modifications on both strands; (b) Particle size distribution: Z-average size ~70 nm as determined by dynamic light scattering (intensity distribution); (c) The Zeta potential of representative DACC lipoplexes lies between 40 and 50 mV as measured at 270 mmol/l sucrose; (d) Electron micrograph of DACC lipoplex particles showing predominantly lamellar structures in mostly spherical arrangements. Bar = 200 nm.