Fig. (5).
Representative illustration of a hyperglycemic clamp with 15 mmol/L arginine stimulation at the 260-min time point. (a) Plasma C-peptide concentrations. Filled circles, baseline. Open squares, Week 52. Hatched squares, Week 56. Mean±SEM (b) Ratios to pretreatment for AIRarg, first-phase secretory response, and second-phase secretory response in patients with type 2 diabetes treated with exenatide 10 µg twice daily for 52 weeks, followed by no drug treatment for 4 weeks. Filled columns, baseline. Open columns, Week 52. Hatched columns, Week 56. Geometric mean±SEM. AIRarg, acute plasma insulin response to arginine; SEM, standard error of the mean. From reference [132].