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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: J Am Chem Soc. 2008 Jun 18;130(28):8975–8983. doi: 10.1021/ja711248y

Figure 4.

Figure 4

The presence of GlcNAc causes a radical rearrangement of oligosaccharides bound to Golgi mannosidase II. Shown is the binding of 3 (blue, from PDB structure 3BVV) and GlcNAc-modified 4 (yellow, from PDB structure 3BVW). For orientation purposes, one of the mannoside residues is colored green. This mannoside binds in the −1 site of D204A/3 complex and in the +3 site of the D204A/4 complex. The active-site zinc is colored magenta. Although 3 is a tetrasaccharide, only three sugars could be assigned to the electron density.