. Author manuscript; available in PMC: 2014 Apr 10.

Published in final edited form as: Focus (Am Psychiatr Publ). 2013 Feb 1;11(1):22–31. doi: 10.1176/appi.focus.11.1.22

Table 3.

Strategies for Universal Depression Prevention Trials.

Approach	Example
Choose the right intervention	Omega-3 supplements and physical activity are examples of interventions with: good Safety, plausible Evidence of potential efficacy, high Acceptability, Low-cost (SEAL).
Leverage research infrastructures	Ancillary studies to existing large-scale trials. Add-in trial within large cohorts or health promotion studies.
Identify at-risk subsets	Testing of selective and indicated prevention among at-risk persons. Utilization of biomarker information to identify mediators and moderators of risk.