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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Cell Rep. 2013 Sep 12;4(6):1197–1212. doi: 10.1016/j.celrep.2013.08.011

Figure 7. The Antioxidant NAC Rescues Myelin and Vascular Phenotypes in PLP;Nf1floxed and CNP-HRas Mice.

Figure 7

Quantification of phenotypes in WT, PLP;Nf1fl+, PLP;Nf1fl/fl, and CNP-HRas animals after 6 weeks of vehicle or NAC treatment, all in optic nerve 1 mm rostral to the chiasm.

(A) Optic-nerve diameter quantified from semithin cross-sections.

(B and C) Quantification of g-ratio (B) and axon diameter (C) of >1,000 axons/genotype measured by electron microscopy.

(D) Quantification of % perivascular area normalized to blood vessel area.

(E) Percentage of astrocyte endfeet with visible GJs (~300 GJs/animal).

(F) Percentage of endothelial TJs with gaps (~50–60 TJs/animal); n = 3–5 animals/genotype.