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. 2014 Feb 4;196(4):1303–1319. doi: 10.1534/genetics.114.161661

Figure 5.

Figure 5

The area of third suborbital bone (SO3) demonstrates a symmetric genetic basis. The third suborbital bone (dashed box in A and B) was scored on the right (A, C, and E) and left sides (B, D, and F), as demonstrated using specimen 159 from our Asty12 pedigree. The total area of this bone (dashed outline of an exemplary bone composed of two fragments in C–F) harbored a genetic basis. Two markers, 55B and 229B, demonstrated LOD values >3.0 on both the right (G) and left (I) sides of the head. Effect plots revealed an intermediate dominant effect for 55B and a cave dominant effect for marker 229B, on both right and left sides of the head (H and J). MQM analyses identified the same two QTL associated with SO3 bone area on the left and right sides (55B, 229B). Three cofactors were found for the right side (26A, 131C, and 223C) (K), only two of which were present on the left side (131C and 223C) (L). No epistatic interactions between cofactors were observed. Bars: 3 mm in A and B (11×) and 1 mm in C and D (20×). In G and I, black line shows marker regression, green line shows HK, and blue line shows EM mapping methods, respectively.