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. 2014 Feb 4;196(4):1303–1319. doi: 10.1534/genetics.114.161661

Figure 7.

Figure 7

The area of fifth suborbital bone (SO5) demonstrates a partially symmetric genetic basis. The fifth suborbital bone (dashed box in A and B) was scored on the right (A, C, and E) and left sides (B, D, and F), as demonstrated using specimen 162 from our Asty12 pedigree. The total area of this bone (dashed outline, C–F) harbored a genetic basis. Markers 216C and NYU53 (which are ∼2 cM apart from one another) both demonstrated a LOD value >3.0 on the right (G) side of the head. A different marker on the same linkage group (2B) demonstrated a significant LOD score for the left side of the head (I). Interestingly, effect plots were nearly identical for the significant markers on the right side (NYU53) (I) and left side (2B) (J). An additional marker, 222E (black, G and H) had a LOD score just below our 3.0 threshold on the left side, and well below 3.0 on the right side. Unexpectedly, MQM analyses revealed two different QTL (on different groups) associated with SO5 area on the right (214F) and left (229B) sides (K and L). On the right, two cofactors were identified (233D and NYU53), while no cofactors were selected on the left (K). Bar, 3 mm (11×). In G and I, black line shows marker regression, green line shows HK, and blue line shows EM mapping methods, respectively.