Table IV.
Pathway enrichment analysis for up- and downregulated genes in gastric cancer tissues.
| Input genes | Pathways | Counta | P-value |
|---|---|---|---|
| Upregulated pathways | hsa04060, cytokine-cytokine receptor interaction | 38 | 3.61.E-11 |
| hsa04512, ECM-receptor interaction | 17 | 3.16.E-07 | |
| hsa04110, cell cycle | 19 | 4.21.E-06 | |
| hsa04640, hematopoietic cell lineage | 13 | 2.40.E-04 | |
| hsa04620, Toll-like receptor signaling pathway | 14 | 3.02.E-04 | |
| hsa04062, chemokine signaling pathway | 20 | 3.18.E-04 | |
| hsa04610, complement and coagulation cascades | 11 | 5.85.E-04 | |
| hsa04510, focal adhesion | 19 | 2.00.E-03 | |
| hsa04115, p53 signaling pathway | 10 | 2.11.E-03 | |
| hsa04514, cell adhesion molecules (CAMs) | 14 | 3.72.E-03 | |
| hsa05222, small cell lung cancer | 10 | 8.79.E-03 | |
| hsa04670, leukocyte transendothelial migration | 12 | 1.11.E-02 | |
| hsa05020, prion diseases | 6 | 1.51.E-02 | |
| hsa04621, NOD-like receptor signaling pathway | 8 | 1.53.E-02 | |
| hsa05200, pathways in cancer | 23 | 2.09.E-02 | |
| hsa05332, graft vs. host disease | 6 | 2.34.E-02 | |
| hsa05322, systemic lupus erythematosus | 10 | 2.40.E-02 | |
| hsa05219, bladder cancer | 6 | 3.13.E-02 | |
| hsa04114, oocyte meiosis | 10 | 4.32.E-02 | |
| hsa04650, natural killer cell mediated cytotoxicity | 11 | 5.53.E-02 | |
| hsa04142, lysosome | 10 | 5.97.E-02 | |
| hsa04630, Jak-STAT signaling pathway | 12 | 6.43.E-02 | |
| hsa04914, progesterone-mediated oocyte maturation | 8 | 7.17.E-02 | |
| Downregulated pathways | hsa00980, metabolism of xenobiotics by cytochrome P450 | 22 | 3.33.E-18 |
| hsa00982, drug metabolism | 22 | 7.29.E-18 | |
| hsa00830, retinol metabolism | 19 | 2.76.E-15 | |
| hsa00140, steroid hormone biosynthesis | 13 | 3.63.E-09 | |
| hsa00500, starch and sucrose metabolism | 11 | 2.00.E-07 | |
| hsa00040, pentose and glucuronate interconversions | 8 | 3.57.E-07 | |
| hsa00590, arachidonic acid metabolism | 12 | 3.95.E-07 | |
| hsa00983, drug metabolism | 10 | 2.69.E-06 | |
| hsa00053, ascorbate and aldarate metabolism | 7 | 5.02.E-06 | |
| hsa00591, linoleic acid metabolism | 8 | 1.04.E-05 | |
| hsa00860, porphyrin and chlorophyll metabolism | 8 | 3.32.E-05 | |
| hsa00010, glycolysis/gluconeogenesis | 10 | 4.64.E-05 | |
| hsa00150, androgen and estrogen metabolism | 8 | 7.27.E-05 | |
| hsa03320, PPAR signaling pathway | 7 | 1.41.E-02 | |
| hsa00051, fructose and mannose metabolism | 5 | 1.59.E-02 | |
| hsa00330, arginine and proline metabolism | 6 | 1.78.E-02 | |
| hsa00071, fatty acid metabolism | 5 | 2.74.E-02 | |
| hsa00030, pentose phosphate pathway | 4 | 3.42.E-02 | |
| hsa00350, tyrosine metabolism | 5 | 3.72.E-02 | |
| hsa00920, sulfur metabolism | 3 | 4.53.E-02 | |
| hsa00340, histidine metabolism | 4 | 5.00.E-02 | |
| hsa00480, glutathione metabolism | 5 | 5.54.E-02 |
a
Count represents the number of input genes assigned to the KEGG pathway.