Table V.
The selected L2L results of genes up- or downregulated in early gastric cancer.
| Input genes | L2L term (PubMed ID) | Description | xa/nb | Binomial P-value |
|---|---|---|---|---|
| Upregulated genes in the gastric cancer tissues | brca_er_neg (11823860) | Genes whose expression is consistently negatively correlated with the gastric cancer tissues estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 145/996 | 7.50E-95 |
| cancer_undifferentiated_meta_up (15184677) | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 25/69 | 2.21E-28 | |
| dox_resist_gastric_up (14734480) | Upregulated in gastric cancer cell lines resistant to doxorubicin, compared to parent chemosensitive lines | 17/48 | 1.44E-19 | |
| stemcell_embryonic_up (12228720) | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 74/1350 | 1.32E-21 | |
| Downregulated genes in the gastric cancer tissues | 5azac_hepg2_up (16854234) | Upregulated in human hepatoma cells (HepG2) following 48 of treatment with 2.5 μM 5-aza-2-deoxycytidine (5azaC) | 60/1311 | 6.61E-20 |
| 5azac-tsa_hepg2_up (16854234) | Upregulated in human hepatoma cells (HepG2) following 24 h of treatment with 2.5 μM 5-aza-2-deoxycytidine (5azaC) and 24 h of treatment with both 5azaC and 500 nM trichostatin A (TSA) | 66/1619 | 3.69E-19 |
a
The number of the input genes annotated to a L2L term.
b
The number of genes in the reference set annotated to a L2L term.