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. 2012 May 31;41(2):721–732. doi: 10.3892/ijo.2012.1505

Figure 7.

Figure 7

Perturbation of regulatory miR expression affects DNMT3b levels in hypermethylator and non-hypermethylator breast cancer cell lines. (A) Hypermethylator breast cancer cells (Hs578T, HCC1937, and SUM185) exhibit significant reduction in DNMT3b mRNA levels following pre-miR transfection for miR-148b, miR-26b, and miR-29c. (B) Non-hypermethylator breast cancer cells (MDA-MB-468, MDA-MB-415, and BT20) display significantly increased DNMT3b mRNA levels following transfection with antagomirs for miR-148b, miR-26b, and miR-29c. Each real-time assay was performed 3–6 times and error bars represent SEM. **p<0.005, ***p<0.0005, compared to untransfected control cells (unpaired t-test).