Table 1.
Clinicopathologic Features in 1187 Patients with Pure DCIS by ER status
| Feature | All Patients | ER-negative DCIS (N=215) | ER-positive DCIS (N=972) | P Value |
|---|---|---|---|---|
|
| ||||
| Age, years, mean (SD) | 56 (11) | 57 (11) | 55 (11) | 0.008 |
|
| ||||
| Size at pathology, cm, mean (SD)1 | 2.5 (2.6) | 2.8 (2.5) | 2.4 (2.7) | 0.057 |
|
| ||||
| Postmenopausal status2 | 857 (72) | 172 (81) | 685 (71) | 0.003 |
|
| ||||
| Hormone replacement therapy | 418 (35) | 86 (40) | 332 (34) | 0.105 |
|
| ||||
| Presentation 3 | 0.083 | |||
| Clinical symptom | 165 (14) | 38 (18) | 127 (13) | |
| Radiologic finding | 1016 (86) | 177 (82) | 839 (87) | |
|
| ||||
| Bilateral cancer | 46 (4) | 7 (3) | 39 (4) | 0.603 |
|
| ||||
| Type of contralateral breast cancer | 0.659 | |||
| DCIS | 36 (77) | 5 (71) | 31 (78) | |
| Invasive cancer | 11 (23) | 2 (29) | 9 (23) | |
|
| ||||
| Multifocal4 | 142 (16) | 41 (23) | 101 (15) | 0.009 |
|
| ||||
| Multicentric5 | 152 (17) | 42 (23) | 110 (15) | 0.014 |
|
| ||||
| Grade 6 | <0.0001 | |||
| 1 | 104 (9) | 4 (2) | 100 (10) | |
| 2 | 450 (38) | 11 (5) | 439 (45) | |
| 3 | 629 (53) | 199 (93) | 430 (44) | |
|
| ||||
| Histology | <0.0001 | |||
| Solid | 239 (20) | 85 (40) | 154 (16) | |
| Papillary | 22 (2) | 1 (0) | 21 (2) | |
| Micropapillary | 41 (4) | 8 (4) | 33 (3) | |
| Cribriform | 133 (11) | 7 (3) | 126 (13) | |
| Combination | 696 (59) | 99 (46) | 597 (61) | |
| Not specified | 56 (4) | 15 (7) | 41 (4) | |
|
| ||||
| Comedonecrosis7 | 398 (36) | 134 (64) | 264 (29) | <0.0001 |
|
| ||||
| Surgery type | 0.008 | |||
| Segmentectomy | 724 (61) | 114 (53) | 610 (63) | |
| Mastectomy | 463 (39) | 101 (47) | 362 (37) | |
Note.—Unless otherwise indicated, data are numbers of patients (percentages).
1
Not recorded in 211 patients.
2
Not recorded in 4 patients.
3
Not recorded in 6 patients.
4
Not recorded in 316 patients.
5
Not recorded in 271 patients.
6
Not recorded in 4 patients.
7
Not recorded in 70 patients.