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PRC regimen reduces AT8-positive neurons in 3xTg-AD mice hippocampus. Representative images showing hippocampus sections immunostained with AT8 antibody, which recognizes abnormally phosphorylated tau, of 12.5–13.5–month-old 3xTg-AD control, 3xTg-AD PRC and WT control mice are shown. Quantification of numbers of AT8-immunoreactive cells is shown (*P < 0.05, 3xTg-AD PRC vs. 3xTg-AD Control, 10–12 samples per group).
