Figure 5.

Effect of oseltamivir treatment on development of anti-HA antibody response in mice after infection and reinfection with A/Anhui/1/2013 (H7N9) influenza virus. BALB/c mice were infected intranasally with 3 MLD₅₀ of A/Anhui/1/2013 (H7N9) influenza virus, and 21 days after initial infection, all surviving mice were reinfected with 18 MLD₅₀ of the same virus. A, Weight loss of naive and oseltamivir-treated mice after reinfection with A/Anhui/1/2013 (H7N9) virus. B, Quantification of anti-HA antibody response after oseltamivir treatment. Hemagglutination inhibition (HI) titers were determined for sera collected 20 days postinfection (p.i.) of 3 MLD₅₀ (1 day prior to reinfection) and 20 days p.i. of 18 MLD₅₀.