Table 2.
Pathogenicity of Influenza A/Anhui/1/2013 (H7N9) Virus in a BALB/c Mouse Model
| Virus Dose (PFU/Mouse) | No. of Mice Survived/ Total No. | Mean Survival Day | Average Percentage of Weight Loss on Indicated Day Postinfection (% Loss Day 0 ± SD) |
Detection of H7N9 Virus at Different Times After Inoculation (Log10 TCID50/mL ± SD) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lungs | ||||||||||
| 3 | 6 | 9 | 12 | 3 | 6 | 9 | 12 | |||
| 102 | 3/5 | 9 ± 15 | 3.9 ± 1.8 | 10.8 ± 5.5 | 18.8 ± 9.2 | 3.4 ± 6.0 | 6.6 ± 0.4 | 6.1 ± 0.8 | 3.7 ± 0.9 | –a |
| 103 | 1/5 | 7 ± 14 | 8.8 ± 3.0 | 21.7 ± 7.0 | 18.4b | 11.6b | 6.9 ± 0.1 | 6.4 ± 0.3 | 4.8b | NA |
| 104 | 0/5 | 6 ± 0 | 12.5 ± 3.2 | 28.6 ± 1.2 | NA | NA | 6.8 ± 0.3 | 6.5 ± 0.4 | NA | NA |
| 105 | 0/5 | 5 ± 1 | 16.1 ± 2.5 | NA | NA | NA | 6.3 ± 0.4 | 5.8 ± 0.5 | NA | NA |
| 106 | 0/5 | 5 ± 0 | 17.1 ± 2.8 | NA | NA | NA | 6.3 ± 0.5 | 5.9 ± 0.3 | NA | NA |
Abbreviations: NA, not applicable (animal deaths occurred between days 5 and 9 postinfection); PFU, plaque-forming units; TCID50, 50% tissue culture infectious dose.
a Data from 2 animals. –, virus not detected by the TCID50 assay (detection limit: 1.5 log10 TCID50/mL).
b Data from 1 animal due to mortality of the other animals.