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. Author manuscript; available in PMC: 2014 Aug 17.
Published in final edited form as: Nat Commun. 2014;5:3321. doi: 10.1038/ncomms4321

Figure 1. Design of membrane-interacting self-assembling molecules.

Figure 1

(a) Chemical structures of PA 1 and PA 2 that conserve the alkyl tail length (hydrophobic tail) and number of lysine residues (cationic charge) but vary the propensity for intermolecular hydrogen bonding adjacent to the tail. (b) Representative fluorescence images of MC3T3-E1 cells that are viable (green, calcein) or dead (red, EthD-1) on coatings of each PA after 4 h of culture (scalebars, 100 μm). (c) Quantification of cell viability from MC3T3-E1 cells on each PA coating including PAs 3–6 that vary the alkyl tail length and number of lysine residues (Supplementary Fig. 2). One-way ANOVA with Tukey post-test. ***p < 0.001, compared to PA 2. (d) lactate dehydrogenase (LDH) release over time of cells seeded on coatings of either PA 1 (blue) or PA 2 (red). Two-way ANOVA with Bonferroni post-test, ***p ≤ 0.001.