Table 3.
Associations between genetic variants in the adrenomedullin pathway and pregnancy outcomes
| Gene | SNP_ID | Ref | Other | Other allele fraction | Birth weight z-score1 | GLT (mg/dL)* | GDM OR† | Preeclampsia OR† |
|---|---|---|---|---|---|---|---|---|
| Caucasian | ||||||||
| ADM § | rs57153895 | A | G | 0.48 | −0.10 (−0.19, −0.01) | −0.64 (−3.10, 1.81) | 1.05 (0.72–1.54) | 1.5 (0.69–2.59) |
| ADM § | rs7935242 | T | C | 0.52 | 0.08 (−0.01, 0.17) | 0.81 (−1.68, 3.30) | 0.98 (0.67–1.45) | 0.95 (0.62–1.44) |
| CALCRL | rs1157699 | C | T | 0.32 | −0.03 (−0.12, 0.07) | −1.95 (−4.54, 0.64) | 0.79 (0.51–1.22) | 1.39 (0.91–2.13) |
| CALCRL | rs6759535 | T | C | 0.54 | −0.07 (−0.16, 0.02) | −0.50 (−2.97, 1.97) | 0.80 (0.54–1.17) | 1.09 (0.72–1.67) |
| CALCRL | rs696574 | T | C | 0.85 | 0.04 (−0.08, 0.17) | 1.38 (−2.11, 4.87) | 1.45 (0.79–2.66) | 0.78 (0.46–1.35) |
| CALCRL | rs840617 | A | T | 0.85 | 0.04 (−0.09, 0.16) | 1.49 (−1.98, 4.95) | 1.42 (0.78–2.61) | 0.89 (0.50–1.57) |
| CFH | rs1061170 | C | T | 0.59 | −0.02 (−0.11, 0.08) | 0.37 (−2.17, 2.90) | 1.14 (0.77–1.71) | 1.29 (0.83–2.00) |
| CFH | rs1065489 | G | T | 0.17 | −0.06 (−0.18, 0.06) | −0.19 (−3.47, 3.09) | 1.37 (0.85–2.21) | 1.30 (0.77–2.20) |
| African-American‡ | ||||||||
| ADM § | rs57153895 | A | G | 0.29 | 0.18 (0.03, 0.34) | 3.83 (−0.9, 8.57) | 1.42 (0.78–2.59) | 0.70 (0.38–1.32) |
| ADM § | rs7935242 | T | C | 0.77 | −0.16 (−0.33, 0) | −4.18 (−9.2, 0.84) | 0.77 (0.40–1.50) | 1.11 (0.58–2.10) |
| CALCRL | rs1157699 | C | T | 0.16 | 0.03 (−0.15, 0.22) | −3.53 (−8.96, 1.89) | 1.26 (0.65–2.44) | 0.42 (0.16–1.11) |
| CALCRL | rs6759535 | T | C | 0.42 | −0.06 (−0.2, 0.09) | −3.96 (−8.27, 0.35) | 0.70 (0.38–1.27) | 0.68 (0.39–1.18) |
| CALCRL | rs696574 | T | C | 0.71 | 0.00 (−0.16, 0.16) | 0.16 (−4.87, 5.19) | 2.35 (1.04–5.27) | 0.66 (0.38–1.17) |
| CALCRL | rs840617 | A | T | 0.71 | −0.01 (−0.17, 0.15) | 0.41 (−4.52, 5.34) | 2.66 (1.13–6.25) | 0.68 (0.39–1.21) |
| CFH | rs1061170 | C | T | 0.61 | −0.08 (−0.22, 0.06) | 4.39 (0.22, 8.57) | 1.80 (0.95–3.42) | 2.02 (1.11–3.68) |
| CFH | rs1065489 | G | T | 0.05 | −0.03 (−0.34, 0.28) | 6.17 (−3.43, 15.77) | -- | -- |
Bold indicates p < 0.05
*
Linear regression model, effect estimate (95% CI) per other allele, adjusting for pregravid BMI, BMI squared, and maternal age
†
Logistic regression model, OR (95% CI) per other allele, adjusting for pregravid BMI and maternal age
‡
Adjusted for probability of Yoruban ancestry
§
Proxies for ADM rs11042725
--Excluded from logistic regression due to < 5 cases among women carrying one or two copies of the minor allele