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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: For Immunopathol Dis Therap. 2012;3(2):125–133. doi: 10.1615/ForumImmunDisTher.2012006065

FIGURE 5.

FIGURE 5

Nitric oxide (NO)–induced upregulation of RKIP in the inhibition of the epithelial-to-mesenchymal transition (EMT). Treatment with NO results in the inhibition of the transcription repressor Snail, which results in the induction of RKIP expression, a metastasis suppressor gene product. Upregulation of RKIP amplifies the inhibition of the nuclear factor (NF)-κB/Snail/Yin Yang (YY) 1 loop. Overexpression of RKIP results in the inhibition of EMT and its knockdown results in the induction of EMT. Together, NO-induced upregulation of RKIP results in the inhibition of EMT.