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. Author manuscript; available in PMC: 2014 Sep 20.
Published in final edited form as: Oncogene. 2013 Apr 1;33(12):1590–1600. doi: 10.1038/onc.2013.92

Table 1.

KRAS and PIK3CA mutations modulate sensitivity to mTOR inhibition

Cell Line Mutational Status PP242 (μM)
KRAS PIK3CA bRAF
SW620 G12V WT WT 7.8
SW480 G12V WT WT 4.6
SK-CO-1 G12V WT WT 4
LS-513 G12D WT WT 3.9
SW1116 G12A WT WT 0.84
LS-174T G12D H1047R WT 0.84
HCT 116 G13D H1047R WT 0.41
HCT 15 G13D E545K WT 0.3
COLO 205 WT WT V600E 0.24
HT-29 WT WT V600E 0.23
COLO 201 WT WT V600E 0.23
Caco-2 WT WT WT 0.22
SW48 WT WT WT 0.09