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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Circ Res. 2008 Nov 7;103(10):1072–1083. doi: 10.1161/CIRCRESAHA.108.183087

Figure 6.

Figure 6

Requirement of miR-208 for cardiomyocyte hypertrophy and fibrosis. (A) Schematic diagram of a heart following thoracic aortic banding (TAB). (B) Sections of hearts of approximately 3-month-old wild-type and miR-208−/− mice are shown following sham operation or TAB for 21 days. High-magnification views of the ventricular wall are shown at the bottom. Trichrome staining identifies fibrosis in blue. Note that hypertrophy and fibrosis are diminished in miR208−/− mice compared with wild-type following TAB. (Reproduced with permission from van Rooij and Olson, J. Clin. Invest. 2007; 117:2369–2376).