Table 2.
Summary of LEXPIT simulation studies (1000 iterations per cell; Risk differences given as %).
| Baseline risk | N [Ref E(Y)]* | Active** | Mean Est | ESE | Mean SE | 95% Coverage |
|---|---|---|---|---|---|---|
| [5.00, -5.29, 3.00]† | ||||||
| 0.5 | 500 [1] | 0 | (5.05, -7.39, 5.03) | (1.60, 3.26, 3.27) | (1.70, 4.65, 4.72) | (96.0, 94.8, 95.4) |
| 1000 [2] | 0 | (5.02, -6.02, 3.71) | (1.16, 1.88, 1.88) | (1.20, 2.58, 2.60) | (95.1, 96.6, 97.1) | |
| 3000 [5] | 0 | (5.01, -5.41, 3.11) | (0.72, 0.59, 0.60) | (0.70, 0.49, 0.50) | (94.8, 95.6, 95.6) | |
| [5.00, -4.60, 3.00] | ||||||
| 1 | 500 [2] | 0 | (4.99, -5.78, 4.17) | (1.86, 2.62, 2.60) | (1.84, 3.86, 3.87) | (94.3, 96.5, 96.5) |
| 1000 [4] | 0 | (4.96, -4.84, 3.23) | (1.33, 1.00, 1.00) | (1.31, 0.78, 0.78) | (93.4, 96.5, 96.1) | |
| 3000 [10] | 0 | (4.99, -4.63, 3.04) | (0.75, 0.32, 0.33) | (0.76, 0.31, 0.32) | (95.4, 96.0, 95.7) | |
| [5.00, -2.94, 3.00] | ||||||
| 5 | 500 [9] | 0 | (5.33, -3.05, 3.09) | (2.65, 0.40, 0.41) | (2.64, 0.37, 0.38) | (94.5, 95.0, 95.2) |
| 1000 [18] | 0 | (5.44, -3.00, 3.04) | (1.72, 0.26, 0.27) | (1.88, 0.25, 0.26) | (96.3, 95.0, 95.0) | |
| 3000 [53] | 0 | (5.60, -3.00, 3.03) | (0.86, 0.13, 0.14) | (1.09, 0.14, 0.15) | (95.4, 94.3, 96.1) |
ESE, Empirical standard error; MSE, Mean squared error
*
Expected number of events in reference group.
**
One or more active constraints.
†
[γ0, β, γ], Simulation values for model, π = βx + expit{γ0 + γz}.