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. 2014 Apr 10;10(4):e1004287. doi: 10.1371/journal.pgen.1004287

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© 2014 Claudius et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) Relative to control PG dissected 6 days AEL (A′, A″), expression of the Spok protein (B′) was undetected while the Phm signal (B″) was weakened in the PG of phm>ecd^RNAi (B) and phm>prp8^RNAi (D′, D″) larvae. Note the moderate reduction in size of PG cells and nuclei in phm>ecd^RNAi (B) compared to a more severe PG deterioration in phm>prp8^RNAi larvae (D). Expression of hEcd restored Spok and Phm expression (C′, C″) and improved the morphology of the Ecd-deficient PG (C). Cell membranes are decorated with CD8::GFP; DAPI stains the nuclei. Panels show single confocal sections. Scale bars, 20 µm. See Figure S1 for RNAi-mediated depletion of Ecd.