Figure 5. Contribution of purifying selection to the RNA editome in primates.

(A) The percentages of macaque editing sites with corresponding editing sites in human and/or chimpanzee (red bars), or genomically encoded in the two species (blue bars), are shown for the total editome (top), or for editing sites in different genomic regions (bottom). (B) The genomic sequences nearby the macaque editing sites were compiled according to the distances to the editing sites. For each 6-nucleotide window, the proportion of divergent sites between human and rhesus macaque are shown for different genomic categories. (C) Distribution of human-macaque synonymous divergent sites nearby the A-to-G editing sites. The codons with RNA-editing sites are highlighted in yellow and each synonymous divergent site in purple. The distribution of synonymous divergence (dS) values near the RNA-editing site, calculated using a 6-codon window, is shown in the lower panel, with the genome-wide dN and dS between human and rhesus macaque indicated by the dotted line.