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. 2014 Apr 10;10(4):e1004047. doi: 10.1371/journal.ppat.1004047

Figure 6. Active invasion is required for adaptive immune responses to T. gondii.

Figure 6

cpsII-OVA parasites were heat-killed, treated with the invasion inhibitor 4-p-bpb or left untreated and administered to mice intraperitoneally. Tetramer-specific and total CD4+ (a) and CD8+ (b) T cell responses were measured from cells isolated from the spleen and lymph nodes (pooled) 10 days post-vaccination. Flow plots are gated on Foxp3−ve CD4+ T cells (a, top) or CD4+ T cells (a, bottom) and the population examined at the bottom of A was enriched for tetramer+ve cells. Flow plots in B are gated on CD8+ T cells. *p<0.05; **p<0.005. AVG±SE.