Table 1.

Cardiovascular-outcome trials with telmisartan and perindopril in patients with controlled blood pressure

Study	Patients	Randomized (n)	Treatment	Duration	Primary outcome*
EUROPA31	Men and women ≥18 years without HF and with CHD	12,218	Perindopril 8 mg/day or matching placebo	Mean follow-up of 4.2 years	Superiority of perindopril versus placebo 488 (8%) on perindopril; 603 (10%) on placebo RRR 20%, 95% CI 9–29
ONTARGET35	Patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage	25,620	Ramipril 10 mg/day; telmisartan 80 mg/day; combination therapy of ramipril 10 mg plus telmisartan 80 mg	Median follow-up of 4.7 years	Noninferiority of telmisartan versus ramipril 1,412 (16.5%) patients on ramipril; 1,423 (16.7%) patients on telmisartan RR 1.01, 95% CI 0.94–1.09 (versus ramipril) Superiority of combination therapy versus ramipril 1,386 (16.3%) patients on combination RR 0.99, 95% CI 0.92–1.07 (versus ramipril)

Notes:

^*CV death, MI, or cardiac arrest in EUROPA; composite outcome of death from CV causes, MI, stroke, or hospitalization for HF in ONTARGET.

Abbreviations: CHD, coronary heart disease; CI, confidence interval; CV, cardiovascular; HF, heart failure; MI, myocardial infarction; RR, risk reduction; RRR, relative risk reduction; EUROPA, EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease; ONTARGET, ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial.