Table 1. mRNA Enrichment in Spinal Neuron Populations.
Gene | HH St. 24 | HH St. 26 | HH St. 30 |
GAD1 | Mid-dorsal cord IN | Medial, mid-dorsal cord and ventral IN | Medial, mid-dorsal cord and ventral IN |
GAD2 | Mid-dorsal cord IN specific | Medial, mid-dorsal cord and ventral IN | Medial, mid-dorsal cord and ventral IN |
GABRA3 | LMC, mid-dorsal cord IN | LMC, mid-dorsal cord IN | LMC, mid-dorsal cord IN |
GABRB3 | LMC, mid-dorsal cord IN | LMC, mid-dorsal cord IN | LMCm, mid-dorsal cord IN |
GABRG2 | Scattered through Cord | Scattered through Cord | Scattered through Cord |
GABBR2 | Scattered through Cord | Scattered through Cord | Scattered through Cord |
ChAT | LMC-specific | LMC-specific | LMC-specific |
CHRM4 | LMC-specific | LMC-specific | LMC-specific |
CHRM5 | Weak in progenitors (specific) | Progenitor specific | Progenitor specific |
CHRNA2 | Pan-neuronal | Pan-neuronal | Pan-neuronal |
CHRNA3 | Pan-neuronal | Pan-neuronal | Pan-neuronal |
CHRNA5 | LMC specific | LMC (higher in LMCm) | LMC (higher in dorsal LMCm) |
CHRNA7 | No expression | LMC (higher in LMCl) | LMC (higher in LMCl) |
CHRNB2 | LMC specific | LMC specific | LMC specific |
SERT1 | No expression | No expression | No expression |
HTR1A | Whole LMC | LMC (higher in dorsal LMCm) | LMC (higher in dorsal LMCm) |
HTR1B | Few LMC neurons | LMCl | LMCm |
HTR4A | Progenitors (weak), LMC | Weak Pan-LMC | Weak Pan-LMC |
GLYT2 | Interneurons | Interneurons | Interneurons |
GLRA1 | Pan-neuronal | Pan-neuronal | Pan-neuronal |
GLRA2 | LMC (weak) | Pan-LMC, some more dorsal IN | Pan-LMC, some more dorsal IN |
GLRB | No Expression | Pan-LMC | Pan-LMC |
VGLUT2 | Interneurons | Interneurons | Interneurons |
GRIN1 | LMC (weak) | LMC, MMC, ventral IN, mid-dorsal cord IN | LMC, MMC, ventral IN, mid-dorsal cord IN |
GRIN2A | No expression | LMCl, some dorsal IN | LMCl, medial IN, dorsal IN |
GRIK1 | Sparse ventromedial IN, dorsal IN | LMCl, sparse medial IN, dorsal IN, ventral progenitors | LMCl, sparse medial IN, ventral progenitors |
GRIK2 | Pan-LMC | Pan-LMC | Pan-LMC |
GRIA1 | Scattered IN | Dorsal IN, scattered ventral IN, specific progenitor domain | Dorsal IN, scattered ventral IN, specific progenitor domain, Scattered LMC |
GRIA2 | All postmitotic neurons | All postmitotic neurons | All postmitotic neurons |
GRM3 | Scattered progenitors | Progenitor-specific | Progenitor-specific |
GRM4 | Ventral LMC specific | Pan-neuronal | Pan-neuronal |
GRM5 | Weak in ventral LMC | Weak in LMC | Weak in LMC |
GRM7 | LMC (weak), medial Isl1+ progenitors | LMC (higher in LMCm), | LMC (higher in LMCm), dorsal IN, medial IN |
GRM8 | Progenitors, ventral LMC | Progenitors, scattered LMC neurons | Progenitors, scattered LMC neurons |
KCC2 | LMC (weak) | LMC (higher in LMCm) | LMC (higher in LMCm) |
NKCC1 | Weak expression on all LMC soma | Weak expression on all LMC soma | Weak expression on all LMC soma |
This table describes the enrichment of mRNAs in spinal cord regions defined in the Results section at various stages.