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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 2. Increased PDLIM3 exon 4 inclusion in DM2 patients.

Figure 2

A) EAA analysis identified an AS event on exon 4 of PDLIM3 mRNA transcript ENST00000284767. The AS area is enlarged and exon 4, more frequently included in DM2 patients, is highlighted in solid gray. B) The box plot shows the increased expression of Affymetrix probe set 2796971 recognizing exon 4, in DM2 patients compared to CTR (n = 10, **** p<0.0001). Values are normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; *** p<0.001).