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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 5. Increased NDUFV3 exon 3 skipping in DM2 patients.

Figure 5

A) EAA analysis identified an AS event on exon 3 of NDUFV3 mRNA transcript ENST00000354250. The AS area is enlarged and exon 3, less frequently included in DM2 patients, is highlighted in solid gray. B) The box plot shows the decreased expression of Affymetrix probe set 3922937 recognizing exon 3, in DM2 patients compared to CTR (n = 10, **** p<0.0001). Values are normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; ** p<0.01).