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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 10. Increased VCL exon 19 skipping in DM2 patients.

Figure 10

A) EAA analysis identified an AS event on exon 19 of VCL mRNA transcript ENST00000211998. The AS area is enlarged and exon 19, more frequently excluded in DM2 patients, is highlighted in solid gray. B) The box plot shows the decreased expression of Affymetrix probe set 3252129 recognizing exon 19, in DM2 patients compared to CTR (n = 10, **** p<0.0001). Values are normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; * p<0.05).