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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 11. Increased MBOAT7 exon 8 inclusion in DM2 patients.

Figure 11

A) EAA analysis identified an AS event on exon 8 of MBOAT7 mRNA transcript ENST00000245615. The AS area is enlarged and exon 8, more frequently included in DM2 patients, is highlighted in solid gray. B) The box plot shows the increased expression of Affymetrix probe set 3870571, recognizing exon 8 in DM2 patients compared to CTR (n = 10; **** p<0.0001). Values were normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; *** p<0.001).