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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 12. Increased DNMT3L exon 12 skipping in DM2 patients.

Figure 12

A) EAA analysis identified an AS event on exon 12 of DNMT3L mRNA transcript ENST00000418993. The AS area is enlarged and exon 12, more frequently excluded in DM2 patients, is highlighted in solid gray. B) The box plot shows the decreased expression of Affymetrix probe set 3934442 recognizing exon 12, in DM2 patients compared to CTR (n = 10, ** p<0.01). Values are normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; ** p<0.01).