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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 13. Increased LAMC2 exon 23 inclusion in DM2 patients.

Figure 13

A) EAA analysis identified an AS event on exon 23 of LAMC2 mRNA transcript ENST00000264144. The AS area is enlarged and exon 23, more frequently included in DM2 patients, is highlighted in solid gray. B) The box plot shows the increased expression of Affymetrix probe set 2371184, recognizing exon 23, in DM2 patients compared to CTR (n = 10, * p<0.05). Values are normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; *p<0.05).