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. 2014 Apr 10;9(4):e93983. doi: 10.1371/journal.pone.0093983

Figure 14. Increased RHPN1 exon 15 bleeding in DM2 patients.

Figure 14

A) EAA analysis identified an AS event on exon 15b of RHPN1 mRNA transcript ENST00000289013. The AS area is enlarged and exon 15b, more frequently included in DM2 patients, is highlighted in solid gray. B) The box plot shows the increased expression of Affymetrix probe set 3119603 recognizing exon 15b in DM2 patients compared to CTR (n = 10, **** p<0.0001). Values were normalized for the levels of the whole transcript. The splice index (SI) is indicated. C) Validation qPCR assays were performed using the specific primer pair indicated as black arrowhead in panel A. Results are shown as fold change (DM2 = 19, CTR = 15; *** p<0.001).