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. 2014 Apr 10;9(4):e94336. doi: 10.1371/journal.pone.0094336

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© 2014 Onoda et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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All scale bars represent 10 μm. (A–C) 6-μm paraffin sections and (D–I) 10-μm frozen sections. A: PVM surrounding the cerebral blood vessels of a 6-week-old control mouse. GFAP-positive astrocytes were very few in number at sites attached to blood vessels with PVMs with small (approximately 1 μm) PAS-positive granules (arrow). B, C: PVM surrounding cerebral blood vessels of a mouse in the UfCB group. The PVM possessed enlarged granules (arrows). Many GFAP-positive astrocytes were observed at sites attached to PVMs with enlarged granules. D: GFAP-positive astrocytes and PAS-positive PVM (arrows) surrounding cerebral blood vessels of mouse in the UfCB group. E–I: Enlarged views of (D). Around one cerebral vessel, GFAP-positive astrocytic end-feet were detected (E, G, H) at a site attached to PVM with enlarged PAS-positive granules (G, 2.2 μm; H, 1.6 μm), but (F, I) not surrounding PVMs with small PAS-positive granules (smaller than 1.1 μm).