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(A) Raw iEEG 10 s epoch from channel HL6 in patient 1. (B) Raw iEEG at extended time scale of 500 ms. (C) Filtered iEEG of panel B with envelope (red line). The envelope satisfies the criteria for an EoI (Stage 1 of detection). (D, E) The peak of the high-frequency activity and the trough coincide at 60 Hz, i.e. the EoI is not separated from low-frequency activity by a trough and the EoI is therefore excluded from acceptance as HFO.
