Table 2. Spatial HFO distribution compared to seizure onset zone (SOZ).
Patient | HFO area [number of channels] | HFO area [% of all channels] | Channels within HFO area | Seizure onset zone (SOZ) | TP | TN | FP | FN | Sens | Spec |
1 | 6 | 11% | HL 1, 6; PL 1, 2; ER 1, 2 | HL 1, 2 | 1 | 49 | 5 | 1 | 50% | 91% |
2 | 3 | 60% | HL 7; HR 2; ER 7 | HL 1; EL 1; HR 1, 2, 3; ER 1, 2 | 1 | 40 | 2 | 6 | 14% | 95% |
3 | 5 | 14% | HL 1; HR 1, 2; AR 1, 2 | HL 1, 2; AR 1, 2 | 3 | 29 | 2 | 1 | 75% | 94% |
4 | 6 | 11% | EL 1, 2; PL 1; HL 1; PR 1; AR 1 | EL 1,2; HL 1,2 | 3 | 49 | 3 | 1 | 75% | 94% |
5 | 29 | 74% | FPR 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15; FAR 4, 5, 6, 7, 10, 11, 12, 13, 14; TR 1, 2, 3, 4, 5, 6, 7 | FPR 1, 2, 3, 4, 9, 10, 11, 12; FAR 5, 6, 13, 14; TR 1, 2, 3, 4 | 15 | 9 | 14 | 1 | 94% | 39% |
6 | 2 | 6% | TLL 28, 29 | TLL 18, 19, 20, 21, 22, 23, 26, 27, 28, 29, 30, 31 TBAL 1, 2, 3 | 2 | 24 | 0 | 13 | 13% | 100% |
Channels with high number of HFOs define the HFO area with a threshold determined by a half maximum. HFO areas and SOZ show partial overlap in all 6 patients. Channel HL1 indicates a bipolar recording from contacts HL2-HL1. For abbreviations of electrode names, see Table 1.