Figure 6. The genomic context around Mettl12 in H. sapiens.

This figure shows a complex region of the human genome that is difficult to annotate either automatically or manually. The combination of DRS and RNA-Seq data for this ∼13 kb region of H. sapiens, chromosome 11, brings greater clarity to the feature annotation in this region, that either dataset individually is incapable of providing. In particular, the DRS data on the forward strand (Track A) clearly identifies the expression of snoRNA57, in the first intron of Mettl12, and several new transcripts for both Mettl12 and C11orf83. The combination of the exon structure seen in the RNA-seq data (Tracks E & F) and the DRS data on the reverse strand (Track K) clearly identify the dominant form of C11orf48 observed in these data. For full details of the individual tracks and layout of this figure, see Figure 1 (caption). See the Materials and Methods section for more details on the H. sapiens RNA-Seq and DRS datasets, and their processing.