Table 1. Routine immunologic function evaluation in 74 BCGosis/BCGitis patients.
without PID* (n = 42) | with CGD* (n = 23) | with HIGM* (n = 2) | with HIES* (n = 1) | with SCID* (n = 2) | with MSMD* (n = 4) | |
Lymphocyte subsets | ||||||
CD3+(%) | 51–77 | 55–71 | 82; 72 | 94 | 9; 11 | 48–57 |
CD3+CD4+(%) | 35–55 | 23–44 | 21; 22 | 52 | 4; 3 | 29–27 |
CD3+CD8+(%) | 13–36 | 31–45 | 49; 45 | 27 | 4; 4 | 17–27 |
CD16+CD56+(%) | 5–35 | 8–17 | 15; 17 | 2 | 2.5; 3.2 | 6–7 |
CD19+(%) | 3–17 | 7–21 | 3; 5 | 4 | 65; 71 | 40–31 |
Immunoglobulin level | ||||||
IgG(g/L) | 3.7–24.8 | 8.6–26 | 1.2; 1.75 | 24.6 | 0.98; 0.57 | 7.2–11.3 |
IgA(g/L) | 0.1–2.24 | 0.81–3.02 | 1.28; 2.49 | 0.38 | 0.067; 0.03 | 0.23–0.98 |
IgM(g/L) | 0.09–3.24 | 1.02–3.27 | 6.76; 55.34 | 3.08 | 0.04; 0.02 | 0.24–1.57 |
IgE(kU/L) | 2.6–390 | 24.5–990 | <2; 3.96 | 129000 | <2 | 7.14–206 |
DHR analysis# (SI*) | >100 | <10 | >100 | >100 | >100 | >100 |
*PID: primary immunodeficiency disease; CGD: chronic granulomatous disease; HIGM: hyper IgM syndrome; HIES: hyper IgE syndrome; MSMD: Mendelian susceptibility to mycobacterial diseases. SI: stimulation index.
DHR analysis: The comparison was based on a stimulation index, which was defined as mean channel fluorescence intensity of PMA-stimulated neutrophils over mean channel fluorescence intensity of unstimulated neutrophils.