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. 2014 Apr 10;9(4):e94485. doi: 10.1371/journal.pone.0094485

Table 1. Routine immunologic function evaluation in 74 BCGosis/BCGitis patients.

without PID* (n = 42) with CGD* (n = 23) with HIGM* (n = 2) with HIES* (n = 1) with SCID* (n = 2) with MSMD* (n = 4)
Lymphocyte subsets
CD3+(%) 51–77 55–71 82; 72 94 9; 11 48–57
CD3+CD4+(%) 35–55 23–44 21; 22 52 4; 3 29–27
CD3+CD8+(%) 13–36 31–45 49; 45 27 4; 4 17–27
CD16+CD56+(%) 5–35 8–17 15; 17 2 2.5; 3.2 6–7
CD19+(%) 3–17 7–21 3; 5 4 65; 71 40–31
Immunoglobulin level
IgG(g/L) 3.7–24.8 8.6–26 1.2; 1.75 24.6 0.98; 0.57 7.2–11.3
IgA(g/L) 0.1–2.24 0.81–3.02 1.28; 2.49 0.38 0.067; 0.03 0.23–0.98
IgM(g/L) 0.09–3.24 1.02–3.27 6.76; 55.34 3.08 0.04; 0.02 0.24–1.57
IgE(kU/L) 2.6–390 24.5–990 <2; 3.96 129000 <2 7.14–206
DHR analysis# (SI*) >100 <10 >100 >100 >100 >100

*PID: primary immunodeficiency disease; CGD: chronic granulomatous disease; HIGM: hyper IgM syndrome; HIES: hyper IgE syndrome; MSMD: Mendelian susceptibility to mycobacterial diseases. SI: stimulation index.

#

DHR analysis: The comparison was based on a stimulation index, which was defined as mean channel fluorescence intensity of PMA-stimulated neutrophils over mean channel fluorescence intensity of unstimulated neutrophils.