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. 2014 Apr 10;9(4):e94586. doi: 10.1371/journal.pone.0094586

Figure 1. Induction of hyperalgesia by LPS in BALB/C mice.

Figure 1

(A) Molecular structure of TET. (B) Latency time of hind-paw licking in the hot-plate test in mice that were treated with LPS at different concentrations and time points. (C) Writhing counts obtained from the acetic acid-induced abdominal constriction test in mice that were treated with LPS at different concentrations and time points. (D and E) Percentages of protection by TET (15, 30, 45 mg/kg) at 6 h after LPS (100 μg/kg) stimulus, as indicated by the hot-plate test (D) or acetic acid-induced abdominal constriction test (E). Indomethacin (5 mg/kg) and morphine (10 mg/kg) were applied as the positive controls. Values are shown as M±SD. *, P<0.05.