Table 3. Univariate and multivariate Cox-regression analysis.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Sex (female)	0.572	0.227–1.442	0.237	6.036	0.876–41.610	0.0679
Age	1.000	0.999–1.000	0.891	0.999	0.999–1.000	0.2497
WHO grade II	3.002	0.932–9.673	0.065	3.367	0.948–11.962	0.0606
WHO grade III	10.198	2.838–36.645	<0.001 (*)	9.588	1.104–83.296	0.0404 (*)
TIMP3b	0.851	0.246–2.941	0.799	0.146	0.021–0.979	0.0475 (*)
p16	0.769	0.247–2.390	0.650	0.996	0.283–3.450	0.9944
1p36	4.962	1.952–12.611	<0.001 (*)	11.005	2.261–53.550	0.0030 (*)
22q	1.143	0.465–2.813	0.771	0.465	0.144–1.516	0.2041
9p	3.352	1.187–9.463	0.0224 (*)	1.881	0.383–9.226	0.4363

Results for univariate and multivariate Cox regression models. For every variable, the estimated hazard ratio HR and its corresponding 95% confidence interval are given, as well as the p-value when testing HR = 1. P-values below 0.05 are marked with a star (*). The categorical variable WHO grade is treated as factor variable, thus HR refers to the comparison of WHO grade II and WHO grade III, respectively, to WHO grade I.