Table 4. Multivariate Cox-regression analysis with variable selection by AIC criterion.

Variable	Multivariate analysis
	HR	95% CI	p-value
Sex (female)	4.727	0.834–26.779	0.0792
WHO grade II	3.239	0.894–11.733	0.0735
WHO grade III	10.347	1.325–80.798	0.0259
TIMP3b	0.175	0.029–1.043	0.0557
1p36	10.447	2.266–48.164	0.0026
22q	0.411	0.135–1.251	0.1174

Results for multivariate Cox regression models with variable selection. For every variable, the estimated hazard ratio HR and its corresponding 95% confidence interval are given, as well as the p-value when testing HR = 1. The categorical variable WHO grade is treated as factor variable, thus HR refers to the comparison of WHO grade II and WHO grade III, respectively, to WHO grade I. The full model before variable selection included the additional variables age, p16, and 9p which were eliminated by stepwise backward selection with standard AIC (Akaike Information Criterion) as model selection criterion. All estimates and p-values in the table are close to the corresponding values before variable selection (see Table 3).