Table 1. Platelet-related properties of the four diastereomers of compound 1.

Diastereomer number and configuration	Platelet Aggregation (IC50, µM, 95% CI)	P2Y12 VASPa Phosphorylation (% inhibition at 10 µM, 95% CI, n = 3)	P2Y1 Calcium Flux (% inhibition at 10 µM, 95% CI, n = 6)
1.1, SPSP	0.15 (0.09 to 0.24)	97.4 (42.2 to 152.7)	73.2 (58.5 to 87.8)
1.2, SPsRP≡SPrRP	0.50 (0.32 to 0.79)b , e	24.3 (−17.2 to 65.9)c	85.7 (75.1 to 96.3)
1.3, SPrRP≡SPsRP	0.24 (0.14 to 0.40)	81.2 (−8.4 to 170.8)	59 (48.5 to 69.5)
1.4, RPRP	0.82 (0.45 to 1.50)e	12.8 (−17.3 to 42.9)d	38.9 (24.1 to 53.6)e

^aVASP, vasodilator-stimulated phosphoprotein.

^bAll comparisons vs. diastereomer 1.1.

^cp<0.05.

^dp<0.01.

^ep<0.001.