Table 1. Results from PME and Scale Up Reactions with Diverse Ligands.

			bench scaleb
entry	ligand (Figure 1)	PMEa ee (%)c	conv (%)d	ee (%)c
1	BINAP, L1	40	>90	80
2	BINAP, L1		>90	66e
3	H8-BINAP, L2	20	>90	48
4	DACH Trost, L3	0	<10	ND
5	Pfaltz, L4	0	15	14
6	SEGPHOS, L5	42	>90	40
7	DIFLUORPHOS, L6	38	>90	88
8	TUNEPHOS, L7	36	>90	78
9	SONIPHOS, L8	50	>90	72
10	P-PHOS, L9	36	>90	80
11	WALPHOS, L10	36	>90	48
12	MANDYPHOS, L11	34	>90	66

^a8.6 μmol of 1a at −50 °C.

^b0.372 mmol of 1a at −78 °C.

^cDetermined by chiral stationary phase (CSP) HPLC.

^dConv determined by ¹H NMR.

^eConducted at −55 °C to simulate PME conditions.