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Energy-minimized hypothetical top-ranked binding pose of 64 (top, green) and 79 (bottom, green) within the X-ray crystal structure of a stalled Top1–DNA cleavage complex cocrystallized with 9 (PDB code 1SC7). Potential hydrogen bonding interactions are indicated by dashed lines. Heavy atom distances appear next to the dashed lines. The stereoview is programmed for wall-eyed (relaxed) viewing.
