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(A) Structures of two HDAC inhibitors, vorinostat and romidepsin. (B) Docked image of vorinostat (red, ball and stick) in the HDAC1 crystal structure (purple mesh; PBD 4BKX). Vorinostat is bound in the 11 Å active-site channel, whereas the 14 Å internal cavity is located adjacent to the catalytic metal (gray sphere).
