Table 1. Acetate Inhibition Experiments.

sample	IC50 (mM)
wild type	7.2 ± 0.54
HDAC1 F205Y	8.0 ± 1.5
HDAC1 Y23A	21 ± 1.5
HDAC1 Y24A	19 ± 1.1
HDAC1 R34A	21 ± 1.6
HDAC1 R36A	16 ± 1.3
HDAC1 C151A	13 ± 1.1

^aIC₅₀ values from at least three independent trials are shown with standard error. Dose-dependent curves and data are shown in Figure S1 and Tables S4–S10.