Table 3. Tissue Biodistribution for [64Cu]6B in Tumor-Bearing Micea.
0.5 h | 1 h | 2 h | 5 h | |
---|---|---|---|---|
blood | 2.50 ± 1.08 | 0.64 ± 0.24 | 0.26 ± 0.13 | 0.06 ± 0.05 |
heart | 0.92 ± 0.27 | 0.32 ± 0.08 | 0.13 ± 0.05 | 0.06 ± 0.01 |
lung | 2.70 ± 0.73 | 0.83 ± 0.11 | 0.45 ± 0.21 | 0.15 ± 0.01 |
liver | 0.73 ± 0.17 | 0.42 ± 0.04 | 0.30 ± 0.06 | 0.21 ± 0.03 |
stomach | 1.02 ± 0.47 | 0.48 ± 0.28 | 0.25 ± 0.06 | 0.10 ± 0.03 |
pancreas | 0.90 ± 0.23 | 0.31 ± 0.19 | 0.13 ± 0.05 | 0.05 ± 0.04 |
spleen | 5.80 ± 2.61 | 2.14 ± 0.58 | 0.65 ± 0.15 | 0.25 ± 0.07 |
fat | 0.87 ± 0.15 | 0.87 ± 1.32 | 0.19 ± 0.10 | 0.05 ± 0.05 |
kidney | 256.11 ± 75.72 | 148.60 ± 48.41 | 65.39 ± 21.16 | 3.54 ± 0.04 |
muscle | 0.33 ± 0.01 | 1.71 ± 2.29 | 0.17 ± 0.05 | 0.05 ± 0.02 |
small intestine | 0.85 ± 0.41 | 1.38 ± 1.89 | 0.26 ± 0.07 | 0.11 ± 0.10 |
large intestine | 0.88 ± 0.42 | 0.77 ± 0.65 | 0.30 ± 0.08 | 0.14 ± 0.05 |
bladder | 3.99 ± 0.26 | 7.06 ± 3.75 | 2.21 ± 0.57 | 1.43 ± 1.41 |
PC-3 PIP | 23.14 ± 2.20 | 29.50 ± 8.10 | 20.46 ± 2.90 | 18.69 ± 2.88 |
PC-3 flu | 1.29 ± 0.12 | 0.66 ± 0.26 | 0.26 ± 0.04 | 0.13 ± 0.03 |
PIP:flu | 19.36 ± 3.98 | 48.41 ± 14.25 | 79.40 ± 15.83 | 146.79 ± 32.30 |
PIP:blood | 9.13 ± 5.23 | 47.47 ± 7.24 | 101.17 ± 6.70 | 1123.96 ± 25.83 |
PIP:muscle | 69.35 ± 4.29 | 91.30 ± 93.17 | 132.99 ± 43.97 | 436.14 ± 202.71 |
Values expressed are in % ID/g ± standard deviation; n = 4 for all tissues.