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Chemical structure of acrylamide-containing 2,5′-thiodipyrimidine and 5-(phenylthio)pyrimidine scaffold Hsp70 inhibitors that were designed to insert into the Hsp70 allosteric pocket and form a covalent bond with Cys267 upon binding. The yellow surface shows the geometry of the allosteric pocket as determined by SiteMap (Schrodinger LLC, New York).
