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Design of the reversible Hsp70 inhibitors and their proposed mode of interaction with the Hsp70 pocket. (a) General strategy that indicates modifications that are explored here in the design of reversible inhibitors (highlighted in blue). (b) Step-by-step process that highlights key modifications that led to 27c, a reversible Hsp70 binder of activity rivaling that of the most potent irreversible inhibitor 1e.
