Figure 6.

Derivative 17a (at 10 μM) was tested in the scanMAX screen (Ambit) against 402 kinases. The TREEspot interaction map for 17a is presented. Only c-Met (red dot on the kinase tree) appears as a potential low-affinity kinase hit of 17a. KINOMEscan’s selectivity score (S) is a quantitative measure of compound selectivity. It is calculated by dividing the number of kinases that bind to the compound by the total number of distinct kinases tested, excluding mutant variants. S(35) = (number of nonmutant kinases with %Ctrl < 35)/(number of nonmutant kinases tested).