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Composite concentration–effect curves for 106 enantiomers. Concentration–effect curves for the enantiomers of 106 demonstrate that only one enantiomer, 106a, is active, potentiating the GluN1/GluN2C receptor to a fitted maximum of 259 ± 8% of control with an EC50 of 18 ± 0.6 μM (n = 6).
